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The Synaptril Formula: What the 575 mg Math Shows
The Synaptril formula is a 575 mg proprietary blend of six ingredients, and 80 mg of its magnesium comes from magnesium glycinate. Simple label math says that compound likely takes 400 to 570 mg, leaving about 5 to 175 mg for the other five. These are estimates, not lab results.
Written by the Synaptril label deskUpdated · 4 min read
The formula01
What is the Synaptril formula?
The Synaptril formula is one proprietary blend of 575 mg per capsule, made of six ingredients. The label prints the total and the order, but not the share of each line.
It also prints one extra number: 80 mg of magnesium, 19% of the Daily Value, "as Magnesium Glycinate from proprietary blend". That number is the key to the math, because it ties one blend line to a known amount.
No other line has a printed amount. So a reader must work from the weights that the numbers allow, as the next sections do (21 CFR 101.36, supplement labeling).
Think of the capsule as a small box with a fixed weight. One item in the box has a known size. The label lists the other five in order, so each one must be smaller than the one before it.
Three steps02
How much of the blend is magnesium glycinate?
Magnesium glycinate likely makes up 400 to 570 mg of the 575 mg blend. That follows from one fact: the compound is only about 14% magnesium by formula weight, and buffered grades reach about 20%.
Divide 80 mg by 0.20 and you get 400 mg. Divide 80 mg by 0.14 and you get about 570 mg. Whatever the grade, the first line takes most of the blend.
Subtract that from 575 mg and little remains. At 400 mg of glycinate, 175 mg is left. At 570 mg, only 5 mg is left. The truth lies somewhere between, and the label does not say where.
- 1Magnesium glycinate80 mg Mg printed
- 2Alpha-lipoic acidnot printed
- 3Butcher's broomnot printed
- 4L-carnitinenot printed
- 5Turmeric (95% curcuminoids)not printed
- 6Coenzyme Q10not printed
Step 1. The label prints 80 mg of magnesium "as magnesium glycinate from proprietary blend".
Step 2. By formula weight, magnesium glycinate is about 14% magnesium; buffered grades run up to about 20%. So 80 mg of magnesium needs about 400-570 mg of the compound.
Step 3. 575 mg minus that leaves about 5-175 mg for alpha-lipoic acid, butcher's broom, L-carnitine, turmeric and CoQ10 together.
Our estimate from the label, not a lab test. A blend has to list its total and its order, not single amounts (21 CFR 101.36, supplement labeling). Magnesium figures from NIH (NIH ODS, Magnesium).
Our estimate from the label, not a number the maker printed.
What remains03
How much is left for the other five ingredients?
About 5 to 175 mg is left for alpha-lipoic acid, butcher's broom, L-carnitine, turmeric and CoQ10 together. Shared five ways, each line is small. If the five were equal, each would hold between 1 and 35 mg.
The label order adds a second limit. Line k weighs at most 575 divided by k, and after the glycinate it can weigh at most 175 divided by k minus one.
| Line | Order ceiling | Tighter estimate | Studied dose |
|---|---|---|---|
| Alpha-lipoic acid | 288 mg | under about 175 mg | 600 mg |
| Butcher's broom | 192 mg | about 88 mg | No brain dose |
| L-carnitine | 144 mg | about 58 mg | 1.5 to 3 g (acetyl form) |
| Turmeric extract | 115 mg | about 44 mg | 90 mg curcumin twice daily |
| Coenzyme Q10 | 96 mg | about 35 mg | 30 to 100 mg typical |
For L-carnitine the studied dose is of a different form, so the gap is wider than it looks (NIH ODS, Carnitine).
Synaptril: from $49 a bottle30 capsules · 2, 3 or 6 bottles · free shipping on 3 or 6 · 60-day money-back guarantee
See packsWhat it means04
What does the formula math mean for you?
It means the capsule is mainly a magnesium product, with small and unknown amounts of five other things. That is not bad. It is just not what the front claims suggest.
It also means the studies on the other five ingredients do not map onto this capsule. Studies of alpha-lipoic acid used 600 mg a day, and our tighter ceiling sits well under that (Linus Pauling Institute, Lipoic Acid).
The fair way to treat the formula is as a gentle magnesium capsule with a long ingredient list. Ask whether you want that, and at that price.
At $49 a bottle on the six-bottle pack, a capsule costs about $1.63 a day. At $89 a bottle, it costs about $2.97. Weigh those against what a plain magnesium product would cost.
A maker could settle the question by printing every amount. Until then, the math is the best we can do. Read the full label on our supplement facts page, and try the ingredients page for each line.
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FAQ05
Questions about the formula math
Why does the label math use 14% and 20%?
Magnesium glycinate is about 14% magnesium by formula weight. Buffered grades with extra magnesium can reach about 20%. The two figures give the low and high ends of our range.
Can the blend math prove the exact amounts?
No. It gives limits, not exact amounts. Only the maker can print the true split, or a lab test can find it. We say likely, about and at most for that reason.
Is a smaller dose of an ingredient harmful?
Not by itself. A small amount is less likely to cause side effects, but it is also less likely to match any studied dose. The label cannot tell you which side you are on.
Who wrote this06
Written and reviewed by
Pages built from the label, the sales page and linked NIH, FDA, CDC, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by an American Synaptril authorized shop, not by the manufacturer or the distributor. We earn money when you buy through our order links.
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More about Synaptril
American Synaptril authorized shop
Ready to try Synaptril?
Start with a medicine check, then choose your pack. Three or six bottles cost less per bottle and ship free, and each pack comes with the 60-day money-back guarantee.
- Secure checkout
- 60-day money-back guarantee
- Ships from the U.S.